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老年性黄斑变性中,在网状假性玻璃膜疣上的看法。

Sivaprasad S, Bird A, Nitiahpapand R, et al.

期刊名称:survey of ophthalmology

卷期:2016年第61卷第5期

摘要

玻璃膜疣已经被作为老年性黄斑变性(AMD)的临床标志。尽管网状假性玻璃膜疣上(RPD)在25年前第一次被描述,但最近由于多模式成像上的特殊特征及对于视觉功能的显著影响PRD才被认为是AMD的另外一种临床表型。与仅患有玻璃膜疣的眼睛相比,患有RPD的眼睛具有更高的风险发展成为晚期AMD。PRD也可以发生在未患有玻璃膜疣的眼睛。与在AMD中受到极大关注的视网膜色素上皮(RPE)的外部特点不同,研究证据暗示RPD与RPE的内在变化有关。因此,近期研究强调了关于AMD发病机制的新研究途径。我们总结了现有对于AMD中患有RPD的眼睛的组织学,影像学及功能的改变的认知并且为AMD群体提供未来研究的观点来讨论。

Drusen have been considered the clinical hallmark of age-related macular degeneration (AMD). Reticular pseudodrusen (RPD), although first described about 25 years ago, have only been recently recognized as an additional clinical phenotype of AMD with distinct characteristics on multimodal imaging and significant impact on visual function. Eyes with RPD are at greater risk of progression to advanced AMD when compared with eyes with drusen only. RPD can also occur in the absence of drusen. Unlike features external to the retinal pigment epithelium that have received most attention in AMD, evidence suggests that RPD are associated with changes internal to the RPE. Therefore, new avenues regarding the pathogenesis of AMD are highlighted by these recent observations. We summarize the current knowledge regarding the histology, imaging, and functional changes in eyes with RPD in AMD and offer concepts of future research for the AMD community to discuss.


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