SCI TOP 10

当前位置:首页>SCI TOP 10

眼自噬:发育,退化和老化

Boya P, Esteban-Martínez L, Serrano-Puebla A, et al.

期刊名称:Progress in Retinal and Eye Research

卷期:2016年第55卷

陆培荣 主任医师,教授,博士生导师。苏州大学附一院眼科主任。苏州大学“东吴学者”高层次人才,入选首届中国眼科未来领袖发展项目(LDP)。中华眼科学会神经眼科学组委员,中国眼科医师协会委员及学组委员,江苏省眼科学会副主任委员,江苏省医学领军人才。

    2016年的诺贝尔生理学或医学奖颁给了日本科学家大隅良典,因为他在阐明细胞自噬的分子机制和生理功能上的开拓性贡献。自噬在视网膜发育,生理老化及重要眼病如黄斑变性和青光眼中起重要作用。现在探究自噬在视觉系统中的作用还是起步阶段,但自噬在维持视网膜正常功能并有望作为失明和其他眼部疾病新的治疗手段。

为TA点赞

摘要

摘要:自噬是促进细胞组分降解和再循环的一种分解代谢途径。蛋白质,脂质和甚至整个细胞器被自噬体吞噬并转运到溶酶体消除。响应于压力,自噬可介导细胞组分的降解,被再循环以产生维持细胞内环境稳定所需的营养和结构。此外,其还在细胞质量控制中,特别是在神经元中发挥重要作用,改变的蛋白质和损伤的细胞器的总负担不能通过细胞分裂分布至子细胞而减少。研究只检查了自噬在视觉系统中的作用。视网膜,一种光敏组织,可通过视神经至大脑视觉皮层检测和传输电脉冲信号。视网膜和眼都暴露于各种环境损害和压力下,包括基因突变和损害其功能的年龄相关改变。在这里,我们回顾了寻求解释视觉功能中自噬重要性的主要研究。我们描述了自噬在视网膜发育和细胞分化中的作用,并讨论自噬调节异常在生理老化和重要疾病,如年龄相关性黄斑变性和青光眼中的影响。我们还解决了自噬在促进光感受器存活中的作用,并讨论了选择性自噬如何提供保护视网膜细胞的替代手段。这些发现强调了自噬在维持适当视网膜功能中的作用并突出了治疗失明和其他眼病的新方法。

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination. In response to stress, autophagy mediates the degradation of cell components, which are recycled to generate the nutrients and building blocks required to sustain cellular homeostasis. Moreover, it plays an important role in cellular quality control, particularly in neurons, in which the total burden of altered proteins and damaged organelles cannot be reduced by redistribution to daughter cells through cell division. Research has only begun to examine the role of autophagy in the visual system. The retina, a light-sensitive tissue, detects and transmits electrical impulses through the optic nerve to the visual cortex in the brain. Both the retina and the eye are exposed to a variety of environmental insults and stressors, including genetic mutations and age-associated alterations that impair their function. Here, we review the main studies that have sought to explain autophagy's importance in visual function. We describe the role of autophagy in retinal development and cell differentiation, and discuss the implications of autophagy dysregulation both in physiological aging and in important diseases such as age-associated macular degeneration and glaucoma. We also address the putative role of autophagy in promoting photoreceptor survival and discuss how selective autophagy could provide alternative means of protecting retinal cells. The findings reviewed here underscore the important role of autophagy in maintaining proper retinal function and highlight novel therapeutic approaches for blindness and other diseases of the eye.


点击下载

CopyRight 2016  兴齐100版权所有 京ICP证060955号
技术支持:示剑网络   http://100.sinqi.com/