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韩国人高血清铁蛋白水平与青光眼之间的关系:康本三星健康研究

Gye HJ, Kim JM, Yoo C, et al.

期刊名称:British Journal of Ophthalmology

卷期:2016年第100卷第12期

摘要

背景/ 目的:旨在调查韩国人群中血清铁蛋白水平与青光眼之间的关系。方法:该回顾性横断面研究包括20128月至20137月在江北三星医院健康筛查中心接受筛查的164029名受试者。所有受试者接受身体检查,回答社会人口和行为问题,并提供实验室分析样品。拍摄双眼数字眼底照片,所有照片由眼科医生复查。眼科医生根据国际地理和流行病学眼科学协会提出的第四版标准以及视网膜神经纤维层和视盘外观来确定眼是否患有青光眼。结果:女性的平均血清铁蛋白水平为56.98ng / mL,男性为223.82ng / mL。调整年龄,血清铁,总铁结合能力(TIBC),转铁蛋白饱和度,白细胞(WBC)计数,高灵敏度C反应蛋白(HsCRP)和总维生素D水平后,血清铁蛋白水平最高四分位数的男性的OR值较最低四分位数男性高(OR = 1.176,95CI 1.030-1.342p = 0.016);我们没有观察到女性之间存在这种关联。铁代谢的其他标记物,如铁水平,转铁蛋白饱和度和TIBC,以及炎症指标,包括WBCHsCRP和总维生素D,与青光眼无关。结论:高血清铁蛋白水平与男性青光眼高风险相关,但与女性无关。因为血清铁蛋白与氧化应激和炎症相关,所以血清铁蛋白可能在青光眼发展中起作用。

BACKGROUND/AIMS:To investigate the association between serum ferritin levels and glaucoma in a South Korean population.METHODS:This retrospective cross-sectional study included 164029 subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013. All subjects underwent a physical examination, answered sociodemographic and behavioural questions, and provided samples for laboratory analyses. A digital fundus photograph of both eyes was taken, and all photographs were reviewed by ophthalmologists. The ophthalmologists determined if an eye had glaucoma based on criteria set forth by the International Society of Geographical and Epidemiological Ophthalmology and the appearance of the retinal nerve fibre layer and optic disc.RESULTS:The mean serum ferritin level was 56.98ng/mL in women and 223.82ng/mL in men. After adjusting for age, serum iron, total iron-binding capacity (TIBC), transferrin saturation, white blood cell (WBC) count, high-sensitivity C-reactive protein (HsCRP) and total vitamin D level, males in the highest quartile for serum ferritin level had a higher OR for glaucoma than males in the lowest quartile (OR=1.176, 95% CI 1.030 to 1.342, p=0.016); we did not observe this relationship among women. Other markers of iron metabolism, such as iron level, transferrin saturation and TIBC, and inflammation measures, including WBC, HsCRP and total vitamin D, were not associated with glaucoma.CONCLUSIONS:High serum ferritin level was associated with a high risk of glaucoma in men, but not in women. Because serum ferritin is related to oxidative stress and inflammation, it might play a role in glaucoma development.


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