Chen L, Pi L, Fang J, et al.
西南地区 干眼症 结膜炎
目的：旨在确定中国西南地区儿童过敏性结膜炎患儿干眼症的患病率。方法：2015年5月至2015年12月期间进行一项单中心，前瞻性，病例对照研究，包括40名具有季节性过敏性结膜炎（SAC）或常年性过敏性结膜炎（PAC）的3-6岁儿童和40名年龄和性别匹配，无过敏史或干眼病史并接受医疗健康检查儿童作为对照。使用干眼评分系统（DESS）对两组进行评价。进行裂隙灯检查，包括泪膜破裂时间（TFBUT）和荧光角膜染色（FCS）。进行相关分析以评价干眼症指标与AC体征和症状之间的关联。结果：病例组干眼症患病率为97.5％（78/80），对照组为27.50％（22/80）。病例组的平均DESS评分为4.75±2.22，对照组为0.80±1.22（p <0.001）。病例组中干眼症的症状较轻（<6）。病例组的平均泪膜破裂时间为6.54±1.48秒，对照组为10.04±1.79秒（p <0.001）。平均FCS分数分别为0.79±1.34和0.21±0.57（p = 0.001）。 DESS评分和TFBUT均与过敏性结膜炎持续时间相关。结论：通过TFBUT评估的SAC和PAC儿童的干眼病发生率高于对照组。然而，干眼症的主观症状（DESS）与客观症状不一致，表明应该对AC儿童的干眼密切评估和治疗。
PURPOSE:To identify the prevalence of dry eye in pediatric population with allergic conjunctivitis in Southwest China.METHODS:A single-centre, prospective, case-control study conducted between May 2015 and December 2015 included 40 children, 3-6years of age, with seasonal allergic conjunctivitis (SAC) or perennial allergic conjunctivitis (PAC) and 40 age- and gender-matched children undergoing medical healthy examination without history of allergy or dry eye as a control. A dry eye score system (DESS) was administered to both groups. Slit-lamp examinations including tear film break-up time (TFBUT) and fluorescent corneal staining (FCS) were performed. Correlation analyses were performed to evaluate associations between measures of dry eye and signs and symptoms of AC.RESULTS:The prevalence of dry eye was 97.5% (78/80 eyes) in cases and 27.50% (22/80 eyes) in controls. Mean DESS score was 4.75±2.22 in the case group and 0.80±1.22 in the control group (p<0.001). Symptoms of dry eye in the case group were mild (<6). Mean tear film break-up time was 6.54±1.48seconds in the case group and 10.04±1.79seconds in the control group (p<0.001). Mean FCS scores were 0.79±1.34 and 0.21±0.57, respectively (p=0.001). The DESS score and TFBUT were both associated with the duration of allergic conjunctivitis.CONCLUSION:The incidence of dry eye assessed by TFBUT was higher in young children with SAC and PAC than in controls. However, subjective symptoms of dry eye (DESS) were inconsistent with objective signs, indicating that close attention should be paid to the evaluation and treatment of dry eye in pediatric population with AC.