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角膜血管化光学相干断层扫描血管造影和靛青绿血管造影

Ang M, Cai Y, MacPhee B, et al.

期刊名称:British Journal of Ophthalmology

卷期:2016年第100卷第11期

关键词:
血管 化光 角膜

摘要

背景/目的:旨在描述一种适用于角膜血管化眼前段成像的光学相干断层扫描血管造影(OCTA)系统,并与靛青绿血管造影(ICGA)相比较。方法:一项患有微生物角膜炎继发角膜血管化患者的回顾性研究,使用一种裂谱振幅相关算法成像系统(AngioVue; Optovue Inc.FremontCaliforniaUSA)进行OCTA扫描,和ICGA图像检查(Spectralis; Heidelberg EngineeringHeidelbergGermany)。使用Bland-Altman 95%一致性限度(LOA)测量OCTAICGA技术在血管化面积方面的一致性。结果:我们比较了64个扫描图像的角膜血管化面积(8只眼,每种血管造影技术4次扫描)。在我们的研究中,ICGA扫描血管化总平均面积为0.49±0.34mm 2OCTA扫描为0.51±0.36mm 2。我们获取了所有OCTA扫描图像质量评分(κ= 0.80)的实际可重复性。 OCTAICGA扫描之间的一致性良好,尽管ICGA测量面积与OCTA相比较小,平均差异为0.03mm 295CI 0.07-0.01)。 LOA范围从0.27下限(95CI 0.34-0.19)到0.20上限(95CI 0.13-0.28p = 0.127)。结论:我们发现,在这项试验性临床研究中,在测量角膜血管化面积时,适用于角膜的快速,非接触性OCTA技术与ICGA相当。需要进一步的前瞻性研究来确认这种相对较新的成像技术是否能替代前段侵入性血管造影技术。

Background/Aim To describe an optical coherence tomography angiography (OCTA) system adapted for anterior segment imaging, compared with indocyanine green angiography (ICGA) in eyes with corneal vascularisation.Methods Retrospective study of subjects with corneal vascularisation secondary to microbial keratitis who had OCTA scans performed using a commercially available split-spectrum amplitude-decorrelation algorithm angiography system (AngioVue; Optovue Inc., Fremont, California, USA) and ICGA images (Spectralis; Heidelberg Engineering, Heidelberg, Germany). The agreement between OCTA and ICGA techniques in terms of area of vascularisation measured, using Bland–Altman 95% limits of agreement (LOA).Results We compared the area of corneal vascularisation in 64 scan images (eight eyes, four scans for each angiography technique). In our series, the overall mean area of vascularisation from the ICGA scans was 0.49±0.34mm2 and OCTA scans was 0.51±0.36mm2. We obtained substantial repeatability in terms of image quality score (κ=0.80) for all OCTA scans. The agreement between OCTA and ICGA scans was good, although ICGA measured a smaller area compared with the OCTA with a mean difference of 0.03mm2 (95% CI 0.07 to 0.01). The LOA ranged from a lower limit of 0.27 (95% CI 0.34 to 0.19) to an upper limit of 0.20 (95% CI 0.13 to 0.28, p=0.127).Conclusions We found that rapid, non-contact OCTA adapted for the cornea was comparable with ICGA for measurement of the area of corneal vascularisation in this pilot clinical study. Further prospective studies are required to confirm if this relatively new imaging technique may be further developed to replace invasive angiography techniques for the anterior segment.


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