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年龄相关性黄斑变性前体:与Inter99眼研究中维生素A的关联和与CFHY402H的相互作用

Munch IC, Toft U, Linneberg A, et al.

期刊名称:Acta Ophthalmologica

卷期:2016年第94卷第7期

摘要

目的:旨在调查非常早期的年龄相关性黄斑变性(AMD)与每日摄入维生素A,β-胡萝卜素,维生素E,维生素C,锌和铜之间的关系,以及与补体因子H CFHY402HAMD相关多态性的和ARMS2 / LOC387715相互作用。方法:一项横断面研究,84830-60岁的受试者来自Inter99眼研究。使用包含198项的食物频率问卷估计每日摄取的维生素和矿物质。在无红光照明下记录数字眼底照片,并进行黄斑玻璃疣>63μm和大量小硬斑黄斑玻璃疣(> 20)μm分类。 结果:摄取维生素A较多可增加黄斑玻璃疣>63μm风险,比值比= 1.82CI95 1.02-3.24p = 0.042),根据招募组,年龄和性别进行调整,将维生素A摄入量的最高四分位数参与者与最低四分位数参与者进行比较。与CFHY402H有显着相互作用(p = 0.038)。在504CFHY402H参与者中,与最低四分位数参与者相比,维生素A摄入量最高四分位数(OR= 2.58; CI95 1.16-5.73p = 0.020)和第二最高四分位数受试者中≥63μm黄斑玻璃疣的相对危险度增加(OR= 3.27; CI95 1.50-7.13p = 0.0029)。进一步调整总脂肪摄入,能量摄入后,血浆胆固醇,体重指数(BMI),吸烟,酒精摄入,教育和身体活动可加强这种关联。结论:在这项横断面研究中,维生素A摄入量增加可提高CFHY402H受试者>63μm黄斑玻璃膜疣风险。该研究支持维生素A可能是早期AMD的危险因素的说法。

PURPOSE:To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.METHODS:Cross-sectional study of 848 subjects aged 30-60years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63μm and numerous (>20) small hard macular drusen as a mean of both eyes.RESULTS:Higher intake of vitamin A increased the risk of having macular drusen >63μm with odds ratio=1.82 (CI95 1.02-3.24, p=0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p=0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63μm was increased in participants in the highest quartile of vitamin A intake (odds ratio=2.58; CI95 1.16-5.73, p=0.020) and in the second highest quartile (odds ratio=3.27; CI95 1.50-7.13, p=0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.CONCLUSIONS:In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.


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