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TFOS DEWS二期泪膜报告 TFOS DEWS II Tear Film Report

MDP W, Argüeso P, Georgiev GA, Holopainen JM, Laurie GW, Millar TJ, Papas EB, Rolland JP, Schmidt TA, Stahl U, Suarez T, Subbaraman LN, Uakhan O, Jones L

期刊名称:The Ocular Surface


泪膜 报告


摘要:泪膜小组委员会成员回顾了泪膜在干眼症中的作用以及干眼症中泪液的生物物理和生化方面的变化。在临床上,干眼症是以泪液量减少,泪膜破裂加速,以及眼球表面泪液蒸发增加为特征的。泪膜由多种物质组成,包括脂质、蛋白、黏液及电解质,这些物质保证了泪膜的稳定性,但它们是如何相互作用的仍是一个积极的研究领域。在干眼症中,泪膜渗透压升高,蛋白质和粘蛋白向其他成分转变可以作为生物学标志。小组委员会建议未来的研究领域应该旨在促进我们更多了解泪膜及其在干眼症中的变化。最终的报告是所有委员会成员以及整个TFOS DEWS Ⅱ成员在审查后共同撰写的。


The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.


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