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TFOS DEWS二期流行病学报告 TFOS DEWS II Epidemiology Report

Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, Na KS, Schaumberg D, Uchino M, Vehof J, Viso E, Vitale S, Jones L

期刊名称:The Ocular Surface

卷期:2017年第15卷第3期

关键词:
流行病学 报告

摘要

摘要:小组委员会审查了干眼症的发病率、危险因素、自然史、患病率以及流行病学调查中的问卷,一份关于对已发表流行数据进行的荟萃分析评估了年龄及性别对干眼症的影响。全球范围的流行调查已经开始着手,干眼症的患病率从5%-50%不等,体征的流行程度要高于症状,且更多样化。在青年以及赤道以南的人群中,仅存在有限的患病率研究,荟萃分析证实患病率增加与年龄相关,然而,在每十年当中,体征的增长要远大于症状。女性比男性有着更高的患病率,尽管只有随着年龄增长,这种差异才更为显著。风险因素可以归类为可更改的,不可更改的,同时也可以归类为可能性大的和非确定性的。亚洲种族基本有一致的危险因素。经济负担,对视力的影响,生存质量,工作效率,疼痛造成的心理及生理影响是相当大的,尤其是工作效率降低带来的影响。根据不同的用途,目前有许多用于评估干眼症的调查问卷。未来的研究应该用来确定不同严重程度的疾病患病率,不同人群的发病率以及潜在风险因素,比如青少年及电子设备的使用。地理分布可能说明气候、环境、及社会经济因素带来的影响。对已治疗和非治疗干眼症的自然史方面的研究尚有限,这是未来研究的一个重要领域。

 

The subcommittee reviewed the prevalence, incidence, risk factors, natural history, morbidity and questionnaires reported in epidemiological studies of dry eye disease (DED). A meta-analysis of published prevalence data estimated the impact of age and sex. Global mapping of prevalence was undertaken. The prevalence of DED ranged from 5 to 50%. The prevalence of signs was higher and more variable than symptoms. There were limited prevalence studies in youth and in populations south of the equator. The meta-analysis confirmed that prevalence increases with age, however signs showed a greater increase per decade than symptoms. Women have a higher prevalence of DED than men, although differences become significant only with age. Risk factors were categorized as modifiable/non-modifiable, and as consistent, probable or inconclusive. Asian ethnicity was a mostly consistent risk factor. The economic burden and impact of DED on vision, quality of life, work productivity, psychological and physical impact of pain, are considerable, particularly costs due to reduced work productivity. Questionnaires used to evaluate DED vary in their utility. Future research should establish the prevalence of disease of varying severity, the incidence in different populations and potential risk factors such as youth and digital device usage. Geospatial mapping might elucidate the impact of climate, environment and socioeconomic factors. Given the limited study of the natural history of treated and untreated DED, this remains an important area for future research.


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