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眼表面和干眼症的Micro RNAS

Rassi, D.M., De Paiva CS, Dias, L.C., et al.

期刊名称:The Ocular Surface

卷期:2017年第15卷第4期

关键词:
干眼症 表面

摘要

摘要:自20世纪90年代首次对微小RNAmiRNA)描述以来,已有60多篇论文描述了miRNA在眼表面和泪腺(LG)上的作用。微小RNAmiRNA)在几种生理事件和疾病调节中都有作用。它们通过阻断信使RNA来抑制基因表达。已知疾病如Sjgren综合征(SS),眼表肿瘤和感染可增加或减少特异性miRNA的表达。这些miRNA在调节炎症,延缓或增强伤口愈合,细胞分化代谢和存活方面起关键作用。该综述描述了目前对miRNA作为生物标志物,疾病调节剂和眼表疾病潜在治疗靶点的理解。

Since the first description of microRNAs (miRNAs) in the 1990s, more than 60 papers have described the role of miRNAs on the ocular surface and lacrimal gland (LG). MicroRNAs (miRNAs) have a role in several physiological events and in mediation of disease. They inhibit gene expression by blocking messenger RNA. Diseases such as Sj gren syndrome (SS), ocular surface neoplasias, and infections are known to increase or reduce the expression of specific miRNAs. These miRNAs play key roles in modulating inflammation, delaying or enhancing wound healing, cell differentiation metabolism, and survival. This review describes the current understanding of miRNAs as biomarkers, mediators of diseases, and potential therapeutic targets in ocular surface diseases.


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