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综述:环境对眼表疾病的影响

Busanello, A., Santucci, D., Bonini, S., Micera, A.

期刊名称:The Ocular Surface

卷期:2017年第15卷第4期

关键词:
疾病 环境

摘要

摘要:在整个生命中,外部和内部环境在正常发育和组织体内平衡以及疾病发病过程中相互作用。表观遗传修饰响应于环境变化而发生,并且在不修饰DNA碱基序列的情况下在控制基因表达中发挥基本作用。老化,炎症,药物,感染和紫外线暴露可能会对表观遗传修饰产生深远的影响,并引发对疾病的敏感性。越来越多的证据表明,表观遗传机制在调节眼表病理生理学中起关键作用。眼部疾病表观遗传因素的评估将引领对治疗靶点和诊断生物标志物潜在用途的进一步研究。本综述检查了可能发生在眼表面微环境中的特异性表观遗传和生物化学机制。在将来的预防和/或治疗特定眼表疾病的方法中,应考虑表观遗传因子与靶点之间的潜在相关性。

Throughout life, external and the internal environments interact in normal development and tissue homeostasis as well as in onset of disease. Epigenetic modifications occur in response to environmental changes and play a fundamental role in controlling gene expression without modification of the DNA base sequence. Aging, inflammation, drugs, infections and ultraviolet exposure may have profound effects on epigenetic modifications and trigger susceptibility to diseases. Increasing evidence has demonstrated that epigenetic mechanisms play a key role in regulating the physiopathology of the ocular surface. The evaluation of epigenetic factors in ocular disease would lead to further investigation regarding the potential use of therapeutic targets and diagnostic biomarkers. This review examines specific epigenetic and biochemical mechanisms that may occur in the ocular surface microenvironment. Potential correlation between epigenetic factors and targets should be considered in future approaches to prevention and/or treatment of specific ocular surface disorders.


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