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影响先天性白内障术后眼压,角膜厚度及角膜生物力学的因素 Factors influencing intraocular pressure, corneal thickness and corneal biomechanics after congenital cataract surgery

Faramarzi, A., Feizi, S., Maghsoodlou, A.

期刊名称:The British journal of ophthalmology

卷期:2017年第101卷第11期

摘要

摘要:目的:本研究旨在比较无晶状体眼患者,原发性和继发性人工晶状体眼患者的眼压(IOP),中央角膜厚度(CCT)和角膜生物力学,以先天性白内障手术后患者为匹配对照,并探讨影响这些变量的因素。方法:本研究包括36只无晶状体眼,47只原发性人工晶状体眼和30只继发性人工晶状体眼。招募了匹配的志愿者的34只正常眼进行比较。比较各组之间Goldmann压平眼压计(IOPGAT)检测的术后眼压,CCT,角膜滞后(CH),角膜阻力系数(CRF)和角膜补偿IOPIOPCC)。将所有手术眼作为一组,采用单因素分析和多元线性回归分析,观察独立因素对IOPGATCCTCHCRFIOPCC的影响。结果:无晶状体,原发性晶状体眼和继发性人工晶状体眼的IOPGAT分别为12.5±0.92,14.7±1.9,13.4±10.613.4±2.315.7±2.0mmHgp <0.001)。CCT分别为559.5±42.7,628.0±61.7,566.8±35.3585.2±41.1μmp <0.001)。 CH分别为10.87±2.47,10.42±2.20,11.84±2.139.74±1.94mm Hgp = 0.019)。 IOPCC分别为(15.91±3.74),(18.40±4.35),(14.58±4.36),(19.05±4.54mmHgp <0.001)。 CRF组间无显著性差异(P = 0.06)。回归分析显示,手术类型与IOPGATp = 0.04),CCTp <0.001)和CHp = 0.006)显着相关。结论:与先天性白内障手术后正常眼相比,治疗眼的IOPGATCCTCHIOPCC存在显著差异。这些变量主要受手术类型的影响。原发性人工晶状体植入保留了角膜结构和前房角功能。

AIMS:This study aims to compare intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanics among patients with aphakia, patients with primary and secondary pseudophakia and matched controls following congenital cataract surgery and to investigate the factors influencing these variables.METHODS:This study included 36 aphakic eyes, 47 primary pseudophakic eyes and 30 secondary pseudophakic eyes. Thirty-four normal eyes of matched volunteers were recruited for comparisons. Postoperative IOP measured with a Goldmann applanation tonometer (IOPGAT), CCT, corneal hysteresis (CH), corneal resistance factor (CRF) and cornea-compensated IOP (IOPCC) were compared among the groups. Univariate analyses and multiple linear regression analyses were used to investigate the influences of independent factors on IOPGAT, CCT, CH, CRF and IOPCC, considering all the operated eyes as one group.RESULTS:IOPGAT was 12.5±0.92, 14.7±1.9, 13.4±2.3 and 15.7±2.0mm Hg in normal, aphakic, primary pseudophakic and secondary pseudophakic eyes, respectively (p<0.001). CCT was 559.5±42.7, 628.0±61.7, 566.8±35.3 and 585.2±41.1μm, respectively (p<0.001). CH was 10.87±2.47, 10.42±2.20, 11.84±2.13 and 9.74±1.94mm Hg, respectively (p=0.019). IOPCC was 15.91±3.74, 18.40±4.35, 14.58±4.36 and 19.05±4.54mm Hg, respectively (p<0.001). There was no significant difference in CRF among the groups (p=0.06). Regression analyses revealed that the type of operation was significantly associated with IOPGAT (p=0.04), CCT (p<0.001) and CH (p=0.006).CONCLUSIONS:IOPGAT, CCT, CH and IOPCC were significantly different in treated eyes compared with normal eyes after congenital cataract surgery. These variables were primarily affected by the type of surgery. Primary intraocular lens implantation preserved corneal structure and function of the anterior chamber angle.


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