SCI TOP 10

当前位置:首页>SCI TOP 10

近视对青光眼和非青光眼患者角膜生物力学的影响 Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients

Chansangpetch, S., Panpruk, R., Manassakorn, A., et al.

期刊名称:Investigative Ophthalmology & Visual Science

卷期:2017年第58卷第12期

摘要

摘要:目的:旨在评价近视对原发性开角型青光眼(POAG)和非青光眼患者角膜生物力学特性的影响,以及青光眼缓解对近视眼的作用。方法:本研究包括66POAG眼(33例近视,33例非近视)和66例正常眼(33例近视,33例非近视)。采用超高速Scheimpflug成像技术测量角膜生物力学参数,包括角膜变形幅度(CDA),向内/向外角膜压平长度(ICAOCA),向内/向外角膜速度(ICVOCV),半径和峰值距离(PD)。结果:65例男性(49%)和67例女性(51%)患者的平均年龄(SD)为59岁(9.82)。在POAG组中,近视明显与较高的CDA(调整后效应= 0.104P = 0.001)和较低的OCV(调整后效应= -0.105P <0.001)相关。在非青光眼组中,近视眼的OCV明显较低(调整后效应= -0.086P <0.001)和CDA较高(调整后效应= 0.079P = 0.001)。除PD以外的所有参数提示青光眼改善了近视对角膜生物力学的影响。 POAG与非青光眼患者的CDAICAOCAICVOCV和半径调整后近视效应百分比差异分别为分别为31.6527.2731.6550.0022.0960.49。结论:近视对POAG和非青光眼角膜的显生物力学性能具有明显影响。角膜生物力学参数的差异表明近视与明显较低的眼球刚度相关。POAG可增强近视对大多数此类参数的影响。

Purpose:We evaluated the impact of myopia on corneal biomechanical properties in primary open-angle glaucoma (POAG) and nonglaucoma patients, and the effect of modification of glaucoma on myopic eyes.Methods:This cross-sectional study included 66 POAG eyes (33 myopia, 33 nonmyopia) and 66 normal eyes (33 myopia, 33 nonmyopia). Seven corneal biomechanical parameters were measured by ultra-high-speed Scheimpflug imaging, including corneal deformation amplitude (CDA), inward/outward corneal applanation length (ICA, OCA), inward/outward corneal velocity (ICV, OCV), radius, and peak distance (PD).Results:Mean age (SD) of the 65 male (49%) and 67 female (51%) patients was 59 (9.82) years. Myopia was associated with significantly higher CDA (adjusted effect = 0.104, P = 0.001) and lower OCV (adjusted effect = -0.105, P < 0.001) in the POAG group. Within the nonglaucoma group, myopic eyes had a significantly lower OCV (adjusted effect = -0.086, P < 0.001) and higher CDA (adjusted effect = 0.079, P = 0.001). All parameters except PD suggested that glaucoma modified the effect of myopia on corneal biomechanics. Percentage differences in the adjusted myopic effect between POAG and nonglaucoma patients was 31.65, 27.27, 31.65, 50.00, 22.09, and 60.49 for CDA, ICA, OCA, ICV, OCV, and radius, respectively.Conclusions:Myopia had a significant impact on corneal biomechanical properties in the POAG and nonglaucoma groups. The differences in corneal biomechanical parameters suggest that myopia is correlated with significantly lower ocular rigidity. POAG may enhance the effects of myopia on most of these parameters.


点击下载

CopyRight 2016  兴齐100版权所有 京ICP证060955号
技术支持:示剑网络   http://100.sinqi.com/