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广域性OCT血管造影分析视乳头周围放射状毛细血管丛密度与神经纤维层厚度关系 Wide-Field OCT Angiography Investigation of the Relationship Between Radial Peripapillary Capillary Plexus Density and Nerve Fiber Layer Thickness

Jia, Y., Simonett, J.M., Wang, J., et al.

期刊名称:Investigative Ophthalmology & Visual Science

卷期:2017年第58卷第12期

摘要

摘要:目的:旨在探讨健康受试者视乳头周围放射状毛细血管丛(RPCP)密度和分布及其与视网膜神经纤维层(NFL)厚度的关系。方法:采用光谱域光学相干断层扫描技术(OCT),分光光学相干断层扫描(OCT),自动成像,款式也OCT血管造影术(OCTA)测量RPCP毛细血管密度(CD)和NFL厚度。结果:10名受试者10只健康眼的宽视野OCTA8×8 mm)显示了RPCP分布在整个后极部。 RPCP-CD随距离视盘距离而减小,但沿弓形神经纤维束相对密集(>半数最大密度),RPCP从视盘延伸超过5mm,并且包括黄斑以上和以下的区域。 RPCP-CDNFL厚度高度相关(R2 = 0.85P <0.001),与非线性叠层模型拟合良好。该模型拟合表明,当NFL厚于17.9μm并且达到84%的最大面积密度时出现RPCPRPCP在当前仪器横向分辨率下具有19%的表观体积密度。这表明,当NFL厚度达到40μm时,可能发生毛细血管重叠。结论:密集重叠的RPCP广泛分布表明,宽域(垂直8mm和水平7mmOCTA扫描可能会更好地研究青光眼或其他视神经病早期阶段的毛细血管缺失情况。

Purpose:To characterize the density and distribution of the radial peripapillary capillary plexus (RPCP) and its relationship with retinal nerve fiber layer (NFL) thickness in healthy subjects.Methods:Using spectral-domain optical coherence tomography (OCT), split-spectrum amplitude decorrelation angiography algorithm and automated montaging, wide-field OCT angiography (OCTA) was used to measure the RPCP capillary density (CD) and NFL thickness. Polar sector-average CD and thickness maps were also created on each eye.Results:Wide-field OCTA (8 × 8 mm) in 10 healthy eyes from 10 subjects demonstrated the distribution of the RPCP throughout the posterior pole. RPCP-CD decreases with distance from the disc, but along the arcuate nerve fiber bundles relatively dense (> half maximum density) RPCP extends more than 5 mm from the disc and includes regions superior to and inferior to the macula. The RPCP-CD and NFL thickness are highly correlated (R2 = 0.85, P < 0.001) and fit well with a nonlinear stacked-layer model. The model fit suggests that the RPCP is present when the NFL is thicker than 17.9 μm and reaches a ceiling area density of 84% and that the RPCP has an apparent volume density of 19% at the current instrument transverse resolution. This indicates that capillary overlap can be expected to occur when NFL thickness reaches 40 μm.Conclusions:The wide distribution of dense overlapping RPCP suggests that wider (up to 8 mm vertical and 7 mm horizontal) OCTA scans may be better investigate capillary loss in the early stages of glaucoma or other optic neuropathies.


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