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青光眼扇区结构与功能关系比较:视网膜神经纤维层的血管密度与厚度比较 Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer

Sakaguchi, K., Higashide, T., Udagawa, S., Ohkubo, S., Sugiyama, K.

期刊名称:Investigative Ophthalmology & Visual Science



摘要:目的:旨在比较视网膜周围神经纤维层(RNFL)的两个结构参数,血管密度(VD)和厚度与青光眼扇区结构 - 功能关系。方法:对129例受试者(青光眼94例,青光眼17例,正常眼18例)的129只眼进行VDOCTRS-3000)光学相干断层扫描(OCT)血管造影(AngioVue/RTVue-XR)检查。使用一种SITA标准24-2程序进行汉弗莱视野(VF)测试。使用一种半偏相关相关系数(sr)和多元线性回归模型(控制性别,年龄,轴长,视盘面积,β和γ-视乳头周围萎缩(PPA)区和信号强度指数(SSI))部分残差图基于Garway-Heath图比较扇区结构 - 功能关系。结果:对于所有VF区,当VD区对应于VF区时,VDsr2最大(sr20.17-0.39 。相比之下,当厚度扇区对应于VF扇区(sr20.02-0.34)时,只有三个扇区是厚度最大的sr2:颞下,颞侧和颞上。在局部加权散点平滑拟合定性评估中,VD部分残差图显示与VF灵敏度的线性关系比厚度线性关系更强。眼SSI越大,VD越高,而PPA区延伸到VD测量区越大,则VD越低。结论:青光眼周围RNFL VD和厚度具有不同的特征性扇区结构-功能关系。

Purpose:To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL).Methods:Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program. Sectoral structure-function relationships based on the Garway-Heath map were compared between VD and thickness using a semipartial correlation coefficient (sr) and partial residual plots determined by multiple linear regression models controlling for the effects of sex, age, axial length, disc area, beta- and gamma- parapapillary atrophy (PPA) zones, and signal strength index (SSI).Results:For all VF sectors, the sr2 of VD was largest when the VD sector corresponded to the VF sector (sr2: 0.17-0.39). In contrast, in only three sectors was the sr2 of thickness largest when the thickness sector corresponded to the VF sector (sr2: 0.02-0.34): the inferior temporal, temporal, and superior temporal sectors. The partial residual plots against VD showed more linear relationships with VF sensitivity than those against thickness in the qualitative evaluation of fitting by locally weighted scatterplot smoothing. Eyes with larger SSI had higher VD, whereas eyes with a larger extension of the PPA zone into the VD measurement area had lower VD.Conclusions:Peripapillary RNFL VD and thickness have different characteristic sectoral structure-function relationships in glaucoma.


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