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全身和局部应用脂肪酸在干眼症治疗中的作用 The role of systemic and topical fatty acids for dry eye treatment

Barabino, S., Horwath-Winter, J., Messmer, E.M., Rolando, M., Aragona, P., Kinoshita, S.

期刊名称:Progress in Retinal and Eye Research

卷期:2017年第61卷

摘要

摘要:干眼症是一种流行的疾病,也是患者寻求眼科医疗护理的主要原因之一。全身低性水平ω脂肪酸是干眼症(DED)的一个风险因素。有两个必需脂肪酸(EFAs):ω-6n-6)家族和ω-3n-3)家族。人类通过饮食摄取,饮食中n-6n-3的比例约为11,然而目前的西方饮食往往缺乏n-3 EFAs,这个比例通常要高得多(接近171)。 EFAs的新陈代谢产生了四个新的局部作用介质家族:脂质素,消退素,保护素和maresins。这些分子具有抗炎和消散前特性。我们对动物模型研究和人类临床试验进行了重要概述,表明膳食改变和口服补充剂可以是治疗干眼症的补充治疗策略。此外,我们还讨论了n-3n-6EFAs局部应用的初步结果,因为这些分子可以作为天然抗炎剂,为整个眼表系统带来阳性变化。

Dry eye is a prevalent condition and one of the main reasons for patients to seek ophthalmic medical care. A low systemic level of omega fatty acids is a risk factor for dry eye disease (DED). There are two groups of essential fatty acids (EFAs): the omega-6 (n-6) family and the omega-3 (n-3) family. Humans evolved on a diet in which the n-6:n-3 ratio was approximately 1:1, however the current Western diet tends to be deficient in n-3 EFAs and this ratio is typically much higher (approaching 17:1). The metabolism of EFAs generates four new families of local acting mediators: lipoxins, resolvins, protectins, and maresins. These molecules have anti-inflammatory and pro-resolution properties. We present a critical overview of animal model studies and human clinical trials that have shown that dietary modification and oral supplementation could be complementary therapeutic strategies for the treatment of dry eye. Furthermore, we discuss preliminary results of the topical application of n-3 and n-6 EFAs because these molecules may act as natural anti-inflammatory agents with positive changes of the entire ocular surface system.


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