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Chow, S.P., Hopkinson, C.L., Tole, D.M., Jones, M.N., Cook, S.D., John, A.W.

期刊名称:The British journal of ophthalmology



摘要:背景和目的:许多角膜移植研究都以移植物失败或排斥为重点,或在术后一个时间点报告视力预后。方法:研究包括20031月至200912月所有患有圆锥角膜(868)或Fuchs内皮营养不良(FED)(569)并在英国接受第一次角膜移植手术的患者。通过多因素logistic回归模型分析角膜移植术后2-5年视力改善或恶化(≥2Snellen线获得或丧失)率。结果:大多数进行穿透性角膜移植术(PK)或深层前角膜层角膜移植术维持视力的圆锥角膜患者保持了视力(651/868; 75%),而15%(133/868)改善,10%(84/868)恶化。 同样,大多数接受PKFED患者保持了视力(395/569; 70%),而18%(105/569)改善,12%(68/569)恶化。

BACKGROUND AND AIMS:Many studies of corneal transplantation focus on graft failure or rejection as endpoints, or report visual outcomes at one postoperative time point. We aimed to study the stability of visual outcomes between 2 and 5 years following corneal transplantation.METHODS:All patients with keratoconus (868) or Fuchs endothelial dystrophy (FED) (569) receiving their first corneal transplant for visual purposes in the UK between January 2003 and December 2009 were included. The probability of visual improvement or deterioration (gain or loss of 2 Snellen lines, respectively) between 2 and 5 years after keratoplasty was modelled by multivariable logistic regression.RESULTS:The majority of keratoconus patients with a penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty maintained their visual acuity (651/868; 75%) while 15% (133/868) improved and 10% (84/868) deteriorated. Similarly, most patients with FED who received a PK maintained their vision (395/569; 70%) while 18% (105/569) improved and 12% (68/569) deteriorated.


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