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梗阻性睑板腺功能不全患者行导管睑板腺探查术后睑板腺组织的生长

Maskin, S.L., Testa, W.R.

期刊名称:The British journal of ophthalmology

卷期:2018年第102卷第1期

摘要

摘要:目的:旨在探讨睑板腺探查(MGP)对梗阻性睑板腺功能障碍(o-MGD)患者上睑睑板腺(MG)区的影响。方法:对o-MGD患者的MGP/后非接触式红外显像检查结果进行了回顾性研究,在总测量区中观察到MG生长迹象。结果:34只眼睑(19例患者,随访≥4.5至≤12个月)的MGP后显像显示41.2MG生长。10只眼睑数据适合进行分析,显示平均个体腺体面积(MIGA)明显增加4.87%(P = 0.0145)(116个腺体)。 10个眼睑中的4个独立显示MIGA显着增加,范围从10.70%至21.13%(p <0.0001p = 0.0277p = 0.0292p = 0.0345),而6个不显着。在> 12个月和<25个月的随访期间,另外16个盖眼睑(9例患者)随访显示25%有MG生长迹象。三个眼睑分析显示,MIGA显着增加(33个腺体)11.19%(p = 0.0004)。三个眼睑中的两个独立地显示MIGA明显增加13.73%和20.00%(p = 0.0097p = 0.0001)。所有13个分析的眼睑(149个腺体)中,总共腺体面积显着增加6.38%(p = 0.0447),MIGA显着增加6.23%(p = 0.0003)。结论:红外线睑板腺成像显示,MGP与增加的MG组织面积和萎缩MGs的生长相关。 MGP通过自然孔口提供了睑板流出道的明确物理证明,并且可以通过直接机械性建立患者导管/孔口系统促进腺体生长。

PURPOSE:To investigate the impact of meibomian gland probing (MGP) on meibomian gland (MG) area from the upper lids of patients with obstructive meibomian gland dysfunction (o-MGD).METHODS:Retrospective study comparing pre-MGP/post-MGP non-contact infrared meibography results in patients with o-MGD, viewing signs of MG growth within total measurement field.RESULTS:Post-MGP meibography of 34 lids (19 patients, 4.5 to 12 months' follow-up) showed 41.2% with MG growth. Ten lids had meibographies suitable for analysis, showing significant collective (116 glands) increase in mean individual glandular area (MIGA) of 4.87% (p=0.0145). Four of 10 lids independently showed significant increase in MIGA, ranging from 10.70% to 21.13% (p<0.0001, p=0.0277, p=0.0292, p=0.0345), while six did not.At >12 and <25 months' follow-up, 16 lids (9 additional patients) had follow-up showing 25% with signs of MG growth. Analysis of three lids showed a significant collective (33 glands) increase in MIGA of 11.19% (p=0.0004). Two of three lids independently showed significant increase in MIGA of 13.73% and 20.00% (p=0.0097, p=0.0001). Collectively, for all 13 analysed lids (149 glands), there was a significant increase of 6.38% in total glandular area (p=0.0447) and a significant increase of 6.23% in MIGA (p=0.0003).CONCLUSION:MGP was associated with increased MG tissue area and growth of atrophied MGs as viewed on meibography. MGP provides unequivocal physical proof of a patent meibum outflow tract through the natural orifice, and may promote glandular growth in part by direct mechanical establishment of a patent duct/orifice system.


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