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Colter, J., Wirostko, B., Coats, B.

期刊名称:Investigative Ophthalmology & Visual Science



摘要:目的:基于透明质酸的聚合物薄膜正在成为局部和连续眼部给药的药物传输载体。高度润滑的透明质酸可以增加舒适度,但是可以取代眼部泪膜,减少药物的暴露和疗效。以前的研究表明,仔细控制膜与眼表面相互作用对于提高药物保留时间是至关重要的。方法:在本研究中,在三个轴向载荷(0.3,0.50.7N)和四个滑动速度(0.3,1.03.0)下,对羧甲基化透明质酸基聚合物(CMHA-S)与甲基纤维素(0.3,0.50.7 N)之间的摩擦相互作用进行定量。结果:静态摩擦系数随速率增加而明显增加(P <0.003),0.330mm / s,分别为0.18±0.080.46±0.13。当甲基纤维素加入到CMHA-S时,摩擦变得更加依赖于速率。动力学摩擦系数不受速率影响,平均为0.15±0.1。甲基纤维素分别使CMHA-S的静摩擦力和动摩擦力分别提高了60%和80%,但在测试过程中也容易发生磨损。结论:这些数据表明甲基纤维素可用于在膜上产生摩擦差异,但在设计中必须考虑甲基纤维素降解速率增加的可能性。

Purpose:Hyaluronic acid-based polymer films are emerging as drug-delivery vehicles for local and continuous drug administration to the eye. The highly lubricating hyaluronic acid increases comfort, but displaces films from the eye, reducing drug exposure and efficacy. Previous studies have shown that careful control of the surface interaction of the film with the eye is critical for improved retention.Methods:In this study, the frictional interaction of a carboxymethylated, hyaluronic acid-based polymer (CMHA-S) with and without methylcellulose was quantified against ovine and human sclera at three axial loads (0.3, 0.5, and 0.7 N) and four sliding velocities (0.3, 1.0, 10, and 30 mm/s).Results:Static coefficients of friction significantly increased with rate (P < 0.003), ranging between 0.18 ± 0.08 and 0.46 ± 0.13 for 0.3 to 30 mm/s, respectively. Friction became more rate-dependent when methylcellulose was added to CMHA-S. Kinetic coefficient of friction was not affected by rate, and averaged 0.15 ± 0.1. Methylcellulose increased CMHA-S static and kinetic friction by 60% and 80%, respectively, but was also prone to wear during testing.Conclusions:These data suggest that methylcellulose can be used to create a friction differential on the film, but a potentially increased degradation rate with the methylcellulose must be considered in the design.


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