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荧光素,泪膜破裂时间评估干眼症患者泪液替代治疗的疗效:一项系统综述和荟萃分析

Michael J. Doughty

期刊名称:OCUL SURF 眼球表面

卷期:第12卷(2014年)2期

摘要

 目的:旨在回顾人工泪液治疗前后已进行荧光泪膜破裂时间(fTBUT)检测的研究的预后。

方法:对同行评议的文章进行了确定,这些文章报告了干眼症约1个月人工泪液治疗前后的fTBUT平均值。使用48个数据集计算fTBUT值(百分比)变化,21项包括适合进行荟萃分析的fTBUT数据变量信息(如报道平的均值SD)。

结果:治疗前的平均fTBUT值从0.9秒至11.8秒不等(组平均4.7±1.7秒,N =48个数据集)。治疗后,这些值从2.2至10.7不等(组平均6.1±2.3秒; P=0.001),治疗作用净增加1.4±1.2秒(范围 - 1.4至+4.5秒)。类似的变化进行了报道,但与没有区分人工泪眼的类型。荟萃分析显示,净作用为1.3秒,变化幅度(如加权SE)为1.1秒。

结论:干眼症患者使用“人工泪液”治疗后,普遍报告称泪膜稳定性出现小幅且可预见的增加,改善净幅度接近33%。

AbstractPurpose To review outcomes of studies where fluorescein-tear breakup time (fTBUT) measurements had been made before and after treatment with artificial tears. Methods Peer-reviewed articles were identified that reported average values for fTBUT before and after approximately 1 month of treatment of dry eye with aqueous-based artificial tears. 48 data sets were used for calculating the net (percentage) change in fTBUT, with 21 including information of variability (as reported SD of average value) of the fTBUT data suitable for a meta-analysis. Results Prior to treatment, average fTBUT values ranged from 0.9 s to 11.8 s (group mean 4.7 +/− 1.7 s, n = 48 data sets). After treatment, these values ranged from 2.2 to 10.7 s (group mean 6.1 +/− 2.3 s; P<.001), with net increase for the treatment effect being 1.4 +/− 1.2 s (range − 1.4 to + 4.5 s). Similar changes were reported regardless of the type of product type. The meta-analysis confirmed a net effect at 1.3 s, with the magnitude of the variability (as a weighted SE) having a similar overall value of 1.1 s. Conclusions Following use of ’artificial tears’ by dry eye patients, a small but predictable increase in tear film stability has generally been reported, the net magnitude of which is close to a 33% improvement. 

 

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