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斜视性弱视中皮层神经元群体注意力调节的退化

Hou C, Kim YJ, Lai XJ, et al.

期刊名称:J Vis

卷期:2016年第16卷第3期

摘要

行为研究已经报道了弱视患者空间注意力降低,空间视觉的发育性异常。然而,视皮质中和这些行为空间注意力欠缺相关的神经元群体还没有被鉴别出来。在此,我们使用功能性MRI通知的脑电图来源成像来测量注意力对有立体视觉盲的斜视性弱视成人视皮质中神经元群体活动的影响。我们显示了与对照组相比,对于弱视眼输入信息的选择性视觉注意力的调节影响,在初级视皮质(V1)和纹状体外视皮质区域hV4 hMT+整体上有降低。退化的注意力调节同样在正常视力眼的hV4hMT+区域发现,但在V1区未发现。这些结果提供了电生理学上的证据,证明了在发育的关键时期正常的双眼视觉输入可能在我们已知的V1V2弱视损害之外,影响视皮质和更高皮层之间的皮质连接,意味着视皮质中注意力调节的不足是弱视患者功能性损害的一种重要组成原因。此外,我们发现V1区域中退化的注意力调节和眼内抑制的程度、弱视的深度相关。这些结果支持了经常在斜视性弱视患者中发现的视觉抑制可能是弱视眼视觉输入的注意力缺失的一种形式的观点。

Behavioral studies have reported reduced spatial attention in amblyopia, a developmental disorder of spatial vision. However, the neural populations in the visual cortex linked with these behavioral spatial attention deficits have not been identified. Here, we use functional MRI-informed electroencephalography source imaging to measure the effect of attention on neural population activity in the visual cortex of human adult strabismic amblyopes who were stereoblind. We show that compared with controls, the modulatory effects of selective visual attention on the input from the amblyopic eye are substantially reduced in the primary visual cortex (V1) as well as in extrastriate visual areas hV4 and hMT+. Degraded attentional modulation is also found in the normal-acuity fellow eye in areas hV4 and hMT+ but not in V1. These results provide electrophysiological evidence that abnormal binocular input during a developmental critical period may impact cortical connections between the visual cortex and higher level cortices beyond the known amblyopic losses in V1 and V2, suggesting that a deficit of attentional modulation in the visual cortex is an important component of the functional impairment in amblyopia. Furthermore, we find that degraded attentional modulation in V1 is correlated with the magnitude of interocular suppression and the depth of amblyopia. These results support the view that the visual suppression often seen in strabismic amblyopia might be a form of attentional neglect of the visual input to the amblyopic eye.


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