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角膜缘基质干细胞

Funderburgh JL, Funderburgh ML, Du Y

期刊名称:The Ocular Surface

卷期:2016年第14卷第2期

摘要

角膜基质包含角膜缘基底膜下间充质细胞,具有成体干细胞的特征。这些“niche细胞,可支持角膜缘上皮干细胞活力。细胞培养时,Niche细胞表现出典型的间充质干细胞表型。这些基质干细胞具有分化成多种细胞类型(包括角膜)的能力,从而为实验和生物工程中所需的稀有细胞提供丰富的来源。基质干细胞也具有重塑病理基质组织,抑制炎症反应和恢复透明度的能力。由于间质干细胞可以通过活检获得,它们为自体干细胞治疗间质混浊提供了可能性。本综述对这个有趣的细胞群的状态进行了概述。

The corneal stroma contains a population of mesenchymal cells subjacent to the limbal basement membrane with characteristics of adult stem cells. These 'niche cells' support limbal epithelial stem cell viability. In culture by themselves, the niche cells display a phenotype typical of mesenchymal stem cells. These stromal stem cells exhibit a potential to differentiate to multiple cell types, including keratocytes, thus providing an abundant source of these rare cells for experimental and bioengineering applications. Stromal stem cells have also shown the ability to remodel pathological stromal tissue, suppressing inflammation and restoring transparency. Because stromal stem cells can be obtained by biopsy, they offer a potential for autologous stem cell treatment for stromal opacities. This review provides an overview of the status of work on this interesting cell population.


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