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结膜杯状细胞的最新研究结果综述

Gipson IK

期刊名称:Progress in Retinal and Eye Research

卷期:2016年第54卷

关键词:
结膜 细胞 结果

摘要

结膜上皮杯状细胞是一类专门分泌粘蛋白到眼表面的细胞。最新研究已经证明了这类细胞的新特性,包括影响这类细胞分化的因素,它们的基因产物以及它们在眼表面的功能。下文的论述概括了最新发现的Spdef作用方面的内容,Spdef是结膜杯状细胞分化过程的转录因子Ets家族的一员,最新发现的杯状细胞产物包括claudin2,Wnt抑制剂Frzb,以及跨膜粘蛋白Muc16。我们对目前关于结膜杯状细胞功能的观点,包括清除碎片和免疫监视也进行了论述,它们是眼表面疾病中杯状细胞群的变化指数。此外,对于结膜细胞生物学的主要问题我们也进行了讨论。

Goblet cells within the conjunctival epithelium are specialized cells that secrete mucins onto the surface of the eye. Recent research has demonstrated new characteristics of the cells, including factors influencing their differentiation, their gene products and their functions at the ocular surface. The following review summarizes the newly discovered aspects of the role of Spdef, a member of the Ets transcription factor family in conjunctival goblet cell differentiation, the newly discovered goblet cell products including claudin2, the Wnt inhibitor Frzb, and the transmembrane mucin Muc16. The current concepts of conjunctival goblet cell function, including debris removal and immune surveillance are reviewed, as are changes in the goblet cell population in ocular surface diseases. Major remaining questions regarding conjunctival cell biology are discussed.


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