SCI TOP 10

当前位置:首页>SCI TOP 10

年龄相关性黄斑变性和网状黄斑病与心血管疾病的关系

Rastogi N, Smith RT

期刊名称:Survey of Ophthalmology

卷期:2016年第61卷第4期

摘要

年龄相关性黄斑变性是发达国家中导致成人失明的主要原因。因此,人们主要致力于了解这种疾病的危险因素和发病机制。网状黄斑病推测是一种亚型老年性黄斑变性,相关的组织学与位于视网膜色素上皮和内段蓝色区域之间的玻璃膜疣样沉积物相关。网状病变更多见于女性和老年组,并与更高的死亡率相关。导致年龄相关性黄斑变性的危险因素包括高血压、吸烟和心绞痛。与年龄相关性黄斑变性和网状黄斑病风险增加相关的几个基因也与心血管疾病有关。根据现在对年龄相关性黄斑变性和网状黄斑病的临床和遗传危险因素的更好认识,人们提出这些眼病是系统性的假设。系统性的病原可能有助于解释为什么网状疾病更多见于女性和一些年龄较轻的患死亡率较高的心血管疾病男性,这个年龄段的患者还无法确诊网状黄斑疾病和年龄相关性黄斑变性。

 

Age-related macular degeneration is the leading cause of adult blindness in the developed world. Thus, major endeavors to understand the risk factors and pathogenesis of this disease have been undertaken. Reticular macular disease is a proposed subtype of age-related macular degeneration correlating histologically with subretinal drusenoid deposits located between the retinal pigment epithelium and the inner segment ellipsoid zone. Reticular lesions are more prevalent in females and in older age groups and are associated with a higher mortality rate. Risk factors for developing age-related macular degeneration include hypertension, smoking, and angina. Several genes related to increased risk for age-related macular degeneration and reticular macular disease are also associated with cardiovascular disease. Better understanding of the clinical and genetic risk factors for age-related macular degeneration and reticular macular disease has led to the hypothesis that these eye diseases are systemic. A systemic origin may help to explain why reticular disease is diagnosed more frequently in females as males suffer cardiovascular mortality at an earlier age, before the age of diagnosis of reticular macular disease and age-related macular degeneration.


点击下载

CopyRight 2016  兴齐100版权所有 京ICP证060955号
技术支持:示剑网络   http://100.sinqi.com/